The novel indolizine derivative inhibitor for acidizing shows an effective corrosion inhibition without the synergism of propiolic alcohol. The inhibitive indolizine derivatives were generated from BQC (Benzyl Quinolinium Chloride a commonly used key compound in acidizing inhibitor) via a moderate 13-dipolar cycloaddition reaction. High Resolution Mass Spectrometry (HRMS) and NMR were used to confirm the detailed chemical structure. The inhibition of two indolizine derivatives in 15 wt.% HCl for N80 steel was studied by weight loss measurement electrochemical analysis and surface studies et al. Without the addition of propiolic alcohol the inhibition efficiency of N80 in 15 wt.% HCl at 90°C merely reaches 80.3% even when 1.0 wt.% of BQC was added. However under the same conditions when the dosage of two indolizine derivatives is only 0.05 wt.% the inhibition efficiency significantly grows to 98.9% and 99.2% respectively. The indolizine derivative could display an excellent protection performance at a much lower concentration. Compared with BQC the active adsorption sites in indolizine derivatives are reinforced and consequently increase the inhibition. The indolizine derivatives exhibit an enlightening economic advantage and offer an eco-friendly inhibitive material. They might be applied as an important component of new acidizing inhibitor in the future.