Fitness-for-service assessments of corrosion flaws in line pipe often use an Effective Area Method approach (e.g., RSTRENG) to estimate criticality. This method evaluates all contiguous combinations of flaw dimensions that can be defined via a detailed profile. The lowest burst pressure of those combinations is considered the estimated burst pressure of the flaw. This paper investigates the use of an effective area approach to estimate the remaining fatigue life of crack-like flaws described by a detailed profile. Using flaws reported from in-line inspection, the burst pressure and fatigue life of all combinations of flaw dimensions were estimated using the CorLAS™ fracture mechanics model. For some profiles, the effective area corresponding to the lowest burst pressure is not the same as the effective area corresponding to the lowest fatigue life. Therefore, additional analyses of flaws with detailed profiles may be warranted when developing remediation plans considering both fatigue life and burst pressure.