Due to its contribution to microbiologically influenced corrosion and potential HS&E consequences hydrogen sulfide (H2S) presents many challenges to oil and gas production operations. Microbiologically generated H2S is often more difficult to address because it is not present at the onset of production but becomes a problem over the course of the lifetime of a well/asset. Many different types of microbes are responsible for H2S production and reservoir souring. These microbes are capable of reducing not only sulfate but most available sulfur compounds that are present in the reservoir. A new class of compounds was recently identified and characterized in the lab as effective inhibitors or microbial sulfidogenesis. In this work we present results from a field trial conducted using one of these chemistries. The trial showed that this novel inhibitor retained activity under downhole conditions and resulted in significant reductions in the H2S produced within the reservoir as well as the levels found at the central gathering facility. These findings further support the potential of these compounds as solutions to reservoir souring and highlight the need for additional field applications.