Fumes from a pharmaceutical production plant and its support facilities are drawn into one of two regenerative thermal oxidizers (RTOs) where they are destroyed to acceptable regulatory standards. Furan and vinyl ester fiberglass reinforced plastic (FRP) ducts are successfully being used to transport the fumes from their origin to the RTOs. The fumes range from concentrated (above upper explosive limit) to dilute (<15% lower explosive limit) mixtures of various chlorinated and non- chlorinated solvents. Each section of the fume transport system (FTS) is specifically designed based on pressures, solvent type, solvent concentration, temperature, moisture and flow. The ducts range in size from 4 to 120 inches (10.2 cm to 3.05m). This paper will discuss the general design, application and performance of each major portion of the FTS. In addition, it will emphasize the importance of ancillary equipment such as access points, grounding, connectors, and relief systems in the design.