This work presents a comparison of the effect generated by a mixed culture of sulfate-reducing bacteria (SRB) isolated from a natural estuary in western Venezuela, on the cathodic protection (CP) of carbon steel under simulated blisters. The laboratory study was carried out simultaneously measuring attack morphology, polarized potential, pH, and sessile growth, inside a simulated blister in a special cell arrangement, using two types of coatings: one 100% solids epoxy, and the other one, a tape type, which consists of the combination of a geo mesh-polypropylene textile and tarred rubber. A potential of -3.2 V vs. Copper Sulfate Electrode (CSE) was applied, which allowed to reach polarized potentials more negative than -950 mV Vs. CSE without the presence of coatings. Various conditions were considered for the study: A) sterile medium, B) sterile medium inoculated with SRB only outside the blister, and C) sterile medium inoculated outside and inside the blister. The correlation of the results for each case allowed the establishment of different comparative tables that could help to improve corrosion management methods of buried or submerged pipelines in presence of SRB. In all cases, a decrease in CP efficiency under the blister was demonstrated.