The corrosion behavior of 316L and Ti6Al4V when immersed in 0.9% NaCl, Hanks Balanced
Salt Solution (HBSS) and HBSS modified with the addition of albumin and fibrinogen at concentrations
similar to that found in blood serum was investigated for the alloys alone and in a galvanic couple
configuration. The results of this investigation indicate that the presence of serum proteins in the Hanks
Balanced Salt Solution increased the corrosion rate of 316L alloy by an order of magnitude, but
decreased the corrosion rate of the Ti6Al4V alloy. However, when the alloys were configured in a
galvanic couple, the corrosion of both alloys was increased by the presence of the proteins in solution as
compared to the same solution not containing any proteins, or 0.9% NaCl electrolyte. These results
indicate that testing of the alloys in solutions not containing proteins in a physiologically relevant
concentration may yield corrosion data that is not representative of the actual materials performance
when implanted in the body.