Combination of a constant composition (CC) crystallization approach together with
atomic force microscopy (AFM) has enabled the elucidation of the mechanisms of the scale
(crystals) formation and dissolution at the molecular level. The new model reveals that the
surfaces may be unable to support etch pits of sufficient size so as to be able to continue the
dissolution process when the crystals are at the nanoscale. These small crystals resist dissolution
even though the aqueous phases may be undersaturated. In addition, the inhibitory effectiveness
of bisphosphonates for both the formation and dissolution of scale (Ca-P crystals) is discussed.