As a result of its excellent corrosion resistance, Alloy 22 (UNS N06022), has been selected a candidate material for the construction of high level nuclear waste storage containers. However, its intergranular corrosion resistance is known to be affected by simulated long term aging at elevated temperatures, and may also be compromised by container closure weld operations. Advances in understanding structure-property relationships for grain boundaries in polycrystalline materials have led to the development of cost-effective thermomechanical processes for the control of grain boundary structures in numerous conventional polycrystalline materials. These processing methods (GBE) have been previously shown to yield significant improvements in resistance to sensitization, intergranular corrosion and stress corrosion cracking. In this study, the applicability of GBE processing to Alloy 22 canister materials will be presented and discussed. The relative intergranular corrosion susceptibility of GBE- processed and conventional wrought Alloy 22 will be presented under conditions of simulated long term aging (i.e. 649°C upto 1000 hours) and closure weld operations.